A study on proximal effects of imidazole bases to Tetraphenyl porphyrin binding systems with gaseous carbon monoxide is investigated. Previous instrumentation is also updated and recalibrated to known literature values. Imidazoles used in this study vary by substituent volume and electron donating abilities. Past studies have shown that increased electron donation at the iron atom result in weaker CO binding to Heme, both from decreased association rates and increased dissociation rates. This study shows opposing results that increased electron density on the iron atom has improved CO association. It seems that there is a delicate balance between sigma and π interactions of the iron and CO moiety. We also consider steric effects of the Iron porphyrin and the different imidazole side chains. The steric effect and electron donating abilities are considered in order to understand why the CO association rates increase with increasing volume of imidazole side chain substituents.
|Advisor:||Lopez, Marco, Slowinski, Kris|
|School:||California State University, Long Beach|
|School Location:||United States -- California|
|Source:||MAI 50/04M, Masters Abstracts International|
|Subjects:||Inorganic chemistry, Organic chemistry|
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