Radiofrequency (RF) and microwave technologies have widespread applications, such as communication, heating, and remote sensing. The advances in these technologies along with advanced computational techniques have become prevalent in the biomedical sciences for new therapeutic and diagnostic methods. RF and microwave frequencies are presently being investigated for therapeutic applications in areas such as cardiology, urology, surgery, ophthalmology and cancer therapy, and for diagnostic applications in cancer detection and organ imaging.
Utilizing the dielectric properties of tissue to detect breast cancer is not a new idea. As early as 1981, Foster suggested that the difference in dielectric properties of tumor and other soft, high water content tissues could be used for tumor detection over a wide range of frequencies. Specifically, microwave imaging is an emerging technique that could probe this contrast in tissue. While simulation of microwave imaging has been looked at in depth, there have not been many cases of instrumental implementation of this technique.
Meaney developed a clinical prototype using microwave tomographic imaging (MTI) technology for breast imaging as early as 2000. Since July 2006, the research interest has been focused on implementation of microwave imaging devices for biomedical applications.
Several important findings have been observed. In vivo permittivity and conductivity of human breast cancer were found to be 15.3% and 22.4% higher than ex vivo at 900MHz and 13.3% and 21.3% at 2.4GHz, respectively. To the best of the author's knowledge, in vivo dielectric properties of human breast cancer at microwave frequencies have not been reported in the literature. Microwave images of several 2D cross sections of a human heel were also shown in this thesis. In conjunction with these findings, this thesis also presents initial results of the research into potential clinical applications, such as microwave thermal imaging and microwave bone screening.
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|Advisor:||Meaney, Paul M.|
|Commitee:||Hartov, Alexander, Hoopes, P. Jack, Paulsen, Keith D., Preece, Alan W.|
|School Location:||United States -- New Hampshire|
|Source:||DAI-B 73/05, Dissertation Abstracts International|
|Subjects:||Biomedical engineering, Medical imaging|
|Keywords:||Bone scanning, Breast cancer detection, Dielectric contrast, Microwave tomographic imaging, Thermal therapy monitoring|
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