Lead chromate is a known human carcinogen whose mechanism and properties of toxicity are poorly understood. Concerns about lead chromate exposure have developed with respect to occupational health risks. While it is acknowledged that lead chromate is a carcinogen, it is not clear what variables contribute to its toxicity. Previous attention has been drawn to the toxic attributes concerning lead chromate's solubility properties, exposure routes, and concentration/time dependency exposures. The overall aim of this study was to examine if particulate size and shape affect localization of cellular chromate compounds in Chinese hamster ovary (CHO) cells and examine the morphological changes the particulates induce. This study found that preparation and supply origin affect the toxicity of lead chromate particulates.
|Advisor:||Stearns, Diane M.|
|Commitee:||Hurst, Stepanie K., Ingram, Jani C.|
|School:||Northern Arizona University|
|Department:||Chemistry and Biochemistry|
|School Location:||United States -- Arizona|
|Source:||MAI 50/04M, Masters Abstracts International|
|Subjects:||Molecular biology, Toxicology, Surgery, Biochemistry|
|Keywords:||Lead chromate particulates, Micrographs, Toxic|
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