Dissertation/Thesis Abstract

Analysis of particulate lead chromate in Chinese hamster ovary cells by transmission electron microscopy
by Rinner, Ginger R., M.S., Northern Arizona University, 2011, 106; 1505024
Abstract (Summary)

Lead chromate is a known human carcinogen whose mechanism and properties of toxicity are poorly understood. Concerns about lead chromate exposure have developed with respect to occupational health risks. While it is acknowledged that lead chromate is a carcinogen, it is not clear what variables contribute to its toxicity. Previous attention has been drawn to the toxic attributes concerning lead chromate's solubility properties, exposure routes, and concentration/time dependency exposures. The overall aim of this study was to examine if particulate size and shape affect localization of cellular chromate compounds in Chinese hamster ovary (CHO) cells and examine the morphological changes the particulates induce. This study found that preparation and supply origin affect the toxicity of lead chromate particulates.

Indexing (document details)
Advisor: Stearns, Diane M.
Commitee: Hurst, Stepanie K., Ingram, Jani C.
School: Northern Arizona University
Department: Chemistry and Biochemistry
School Location: United States -- Arizona
Source: MAI 50/04M, Masters Abstracts International
Source Type: DISSERTATION
Subjects: Molecular biology, Toxicology, Surgery, Biochemistry
Keywords: Lead chromate particulates, Micrographs, Toxic
Publication Number: 1505024
ISBN: 9781267115003