Dissertation/Thesis Abstract

Endocrine disruption and hepatic protein expression in contaminant-exposed English sole in the southern California bight
by Waggoner, Claire Michelle, M.S., California State University, Long Beach, 2011, 151; 1504550
Abstract (Summary)

It has been well documented that many southern California marine environments are contaminated with anthropogenic compounds. Some of these compounds are suspected to disrupt endocrine and physiological functions in organisms, and their presence is often associated with historically released and current wastewater discharges, including from wastewater treatment plants (WWTPs). This study measured endocrine parameters and hepatic contaminant concentrations in the flatfish, English sole (Pleuronectes vetulus), resident at a WWTP outfall location and two far-field reference locations. Hepatic protein expression was measured in the same individuals using 2D-GE coupled with MADLI-TOF/TOF MS and de novo sequencing to identify differentially expressed proteins. Fish residing at the outfall location had higher tissue levels of many organic contaminant compounds, disrupted endocrine systems, and altered protein expression. Contaminants were significantly related to the endocrine disrupted conditions and to expression of a variety of hepatic proteins representing functions including: cell signaling, detoxification, oxidative stress and metabolism.

Indexing (document details)
Advisor: Kelley, Kevin M.
School: California State University, Long Beach
School Location: United States -- California
Source: MAI 50/03M, Masters Abstracts International
Subjects: Molecular biology, Endocrinology, Environmental Studies, Aquatic sciences
Keywords: Pleuronectes vetulus
Publication Number: 1504550
ISBN: 978-1-124-99492-5
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