Depression is a serious but common medical condition in the United States. The aim of the present study was to understand the influence of common day lifestyles such as excessive workload or marital status on depression. The study also examined the moderating effect of gender. In 2007 the Data from the California Health Interview Survey were analyzed to investigate the association between marital status and depression as well as workload level and depression. As predicted, working adults who were single or living without a partner had a higher rate of self-reported depression than their married counterparts. This phenomenon was found to be more prevalent in single women than in single men. However, an excessive amount of workload (> 50 hours per week), regardless of gender, was not significantly associated with higher rates of depression. Possible explanations as well as implications and recommendations were discussed.