This pilot study investigated if a powered toothbrush significantly reduced the concentration of MCP-1 and RANTES over time in a gingivitis population, when compared to a manual toothbrush. Twenty gingivitis patients, 18-65 years of age with pocket depths ≤6mm and a minimum of 10% bleeding upon probing were enrolled. Participants were seen for 5 study visits and gingival crevicular fluid samples were collected at baseline and 24 weeks. With the exception of race (p=0.01), no statistically significant differences were found between the groups at baseline in clinical measurements, GCF levels of MCP-1 and RANTES and demographics. When comparing the treatment group to the control, no statistical differences were found between the GCF levels for MCP-1 and RANTES at baseline and 24 weeks post treatment (p=0.20 and p=0.19, respectively). Additional large sample studies are needed to determine if these findings can be confirmed.
|Advisor:||Jared, Heather L., Wilder, Rebecca S., Barros, Silvana P.|
|School:||The University of North Carolina at Chapel Hill|
|Department:||Dentistry: Dental Hygiene|
|School Location:||United States -- North Carolina|
|Source:||MAI 46/06M, Masters Abstracts International|
|Keywords:||GCF levels, Gingivitis, MCP-1, Powered toothbrush, RANTES|
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