Dissertation/Thesis Abstract

The impact of folate deficiency on the base excision repair pathway: Analysis of enzyme coordination in response to DNA damage and imbalanced repair
by Pilling, Amanda B., Ph.D., Wayne State University, 2011, 145; 3466675
Abstract (Summary)

The condition of folate deficiency has been implicated in carcinogenesis, with the strongest evidence formulated in colon cancer. The role of folate in DNA repair, DNA synthesis and methylation reactions renders this nutrient an valuable target for studying the onset and progression of cancer. Using molecular techniques to determine gene and protein expression, enzyme activity and methylation status elucidates the mechanism of DNA repair and damage in folic acid deficient animals in response to carcinogen. The findings presented in this study indicate failure to remove and repair damage in the condition of folate deficiency and suggest that the accumulation of DNA base lesions and damage can result in clonogenic selection of initiated cells, driving carcinogenesis.

Indexing (document details)
Advisor: Heydari, Ahmad R.
Commitee: Cabelof, Diane C., Shekhar, Malathy, Zhou, Kequan
School: Wayne State University
Department: Nutrition and Food Science
School Location: United States -- Michigan
Source: DAI-B 72/10, Dissertation Abstracts International
Source Type: DISSERTATION
Subjects: Nutrition, Oncology
Keywords: Carcinogenesis, DNA repair, Folate deficiency
Publication Number: 3466675
ISBN: 9781124802787
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