Dissertation/Thesis Abstract

A study of Latent Autoimmune Diabetes in Adults and ketosis prone type 2 diabetes mellitus
by Djekic, Kristina, M.S., California State University, Long Beach, 2011, 84; 1493112
Abstract (Summary)

Latent Autoimmune Diabetes in Adults (LADA) is an ill-defined autoimmune disorder separated from typical type 1 diabetes (DM-1), because of features suggestive of type 2 diabetes (DM-2). To better understand LADA, we compared it with ketosis prone type 2 diabetes (KPDM-2)—another ‘mixed’ diabetes form of DM-2 with features of DM-1. We measured clinical and biochemical criteria used in the definition of metabolic syndrome to test the degree of similarity of LADA and KPDM-2 to DM-2. LADA was leaner with fewer metabolic syndrome characteristics than KPDM-2, suggesting that LADA resembles DM-1 and KPDM-2 resembles DM-2, despite suggestion of overlap. We conclude that ‘type 2-like’ features of LADA are likely due to age, with little difference between LADA and type 1 diabetes. LADA patients should be treated like all other autoimmune diabetes patients, with early screening to enable diagnosis and early insulin therapy that might prevent lifelong complications of diabetes.

Indexing (document details)
Advisor: Brusslan, Judy
School: California State University, Long Beach
School Location: United States -- California
Source: MAI 49/05M, Masters Abstracts International
Subjects: Endocrinology, Immunology
Publication Number: 1493112
ISBN: 978-1-124-62272-9
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