Dissertation/Thesis Abstract

Orphanin FQ acts through opioid receptor-like receptor-1 in β-endorphin neurons in the arcuate nucleus of the hypothalamus that project to the medial preoptic nucleus to facilitate lordosis
by Sanathara, Nayna Mahesh, M.S., California State University, Long Beach, 2010, 68; 1490335
Abstract (Summary)

Ovarian hormones, estradiol and progesterone regulate hypothalamic neurocircuits that control sexual receptive behavior, lordosis. Estradiol primes a multi-synaptic circuit in the arcuate nucleus of the hypothalamus (ARH) that stimulates the release of the neurotransmitter β-endorphin (β-END) which activates and internalizes the μ-opioid receptor (MOP) medial preoptic nucleus (MPN) neurons. Progesterone acts on estradiol primed neurocircuits to facilitate lordosis by reversing MOP internalization. Data collected supported my original hypothesis that orphanin FQ (OFQ) acts on β-END neurons to facilitate lordosis by inhibiting MOP MPN activation. I demonstrated the presence of mRNA for the OFQ receptor, ORL-1, in proopiomelanocortin (POMC/β-END) neurons in ARH that project to the MPN using retrograde tract tracing with fluorescent in situ hybridization. My second study demonstrated that antagonism of ORL-1 reduced estradiol-induced sexual receptivity. Together these studies demonstrate that POMC (β-END) neurons project to the MPN and express ORL-1 that are important for estradiol facilitated lordosis.

Indexing (document details)
Advisor: Sinchak, Kevin
School: California State University, Long Beach
School Location: United States -- California
Source: MAI 49/04M, Masters Abstracts International
Subjects: Neurosciences, Endocrinology
Publication Number: 1490335
ISBN: 978-1-124-54782-4
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