Ovarian hormones, estradiol and progesterone regulate hypothalamic neurocircuits that control sexual receptive behavior, lordosis. Estradiol primes a multi-synaptic circuit in the arcuate nucleus of the hypothalamus (ARH) that stimulates the release of the neurotransmitter β-endorphin (β-END) which activates and internalizes the μ-opioid receptor (MOP) medial preoptic nucleus (MPN) neurons. Progesterone acts on estradiol primed neurocircuits to facilitate lordosis by reversing MOP internalization. Data collected supported my original hypothesis that orphanin FQ (OFQ) acts on β-END neurons to facilitate lordosis by inhibiting MOP MPN activation. I demonstrated the presence of mRNA for the OFQ receptor, ORL-1, in proopiomelanocortin (POMC/β-END) neurons in ARH that project to the MPN using retrograde tract tracing with fluorescent in situ hybridization. My second study demonstrated that antagonism of ORL-1 reduced estradiol-induced sexual receptivity. Together these studies demonstrate that POMC (β-END) neurons project to the MPN and express ORL-1 that are important for estradiol facilitated lordosis.
|School:||California State University, Long Beach|
|School Location:||United States -- California|
|Source:||MAI 49/04M, Masters Abstracts International|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be