Absolute rate constants and degradation efficiencies for hydroxyl radical, hydrated electron, and hydrogen atom reactions with a library of sulfa drug antibiotics, in water have been evaluated using a combination of electron pulse radiolysis/absorption spectroscopy and steady-state radiolysis/HPLC measurements. Values for hydroxyl radical oxidation yielded an average rate constant of 8.36 ± 0.20 x 109 M-1 s -1, with a corresponding degradation efficiency average of 43.3 ± 4.3%.
The reduction of these compounds by their reaction with the hydrated electron occurred with varied rate constants ranging from: 0.08 – 2.8 x 1010 M-1 s-1, with efficiencies in the range of 0.1 - 82.7%. The rate constants for the hydrogen atom were also measured, and much like the hydroxyl numbers, a constant value of 7.00 ± 0.48 x 108 M-1 s-1 was measured. The consistency of the hydrogen atom and hydroxyl radical reaction rate constants suggests a common initial reaction mechanism.
|Advisor:||Cohlberg, Jeffrey A., Mezyk, Stephen Peter|
|School:||California State University, Long Beach|
|School Location:||United States -- California|
|Source:||MAI 49/04M, Masters Abstracts International|
|Subjects:||Physical chemistry, Organic chemistry|
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