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Dissertation/Thesis Abstract

Immunologic aspects of urothelial carcinomas of the urinary bladder: The role of T cell costimulation and coinhibition.
by Inman, Brant Allen, M.S., College of Medicine - Mayo Clinic, 2011, 108; 1489545
Abstract (Summary)

The immune system is an important defense mechanism against cancer and is often dysfunctional in patients with malignancies. The central regulator of the anti-cancer adaptive immune response is the T lymphocyte. T lymphocyte activation requires the completion of a carefully orchestrated series of specific steps that can be preempted or disrupted by any number of critical events. Particularly important is the provision of a costimulatory signal, the binding of accessory molecules on the antigen presenting cell to receptors on the T lymphocyte. Though costimulatory signals were traditionally envisioned as a T lymphocyte-activating events, recent discoveries have highlighted their duality: they can be either stimulatory (costimulation) or inhibitory (coinhibition). In this thesis I examine programmed death ligand-1 (PD-L1) mediated coinhibition as a mechanism for bladder cancer stage progression. I also present evidence for the role of PD-L1 in granulomatous inflammation in a wide variety of granulomatous disorders. Lastly, I discuss the development of a novel diagnostic test for detecting soluble PD-L1 present in biological fluids and demonstrate its sensitivity, specificity and calibration in patients with cancer.

Indexing (document details)
Advisor: Kwon, Eugene D.
Commitee: Dong, Haidong, Leibovich, Bradley C., Tindall, Donald
School: College of Medicine - Mayo Clinic
Department: Clinical and Translational Science
School Location: United States -- Minnesota
Source: MAI 49/04M, Masters Abstracts International
Subjects: Medicine, Epidemiology, Immunology, Oncology
Keywords: B7-H1, Bladder cancer, Costimulation, Granuloma, Programmed death ligand 1, T lymphocyte
Publication Number: 1489545
ISBN: 978-1-124-51536-6
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