Dissertation/Thesis Abstract

Function and regulation of Drosophila myc during wing growth
by Wu, Din-Mei Christine, Ph.D., Columbia University, 2010, 150; 3442850
Abstract (Summary)

The coordination of growth and pattern is complex and is essential for development. In the following work, we examine the role of the highly conserved growth regulator dMyc in this process during the development of the Drosophila wing imaginal disc. We find that the dynamic expression pattern of dMyc correlates with specific patterning events and also with the differential regional growth rates in the wing imaginal disc. The pattern of dMyc expression, however, is not required for the stereotypic growth of the different regions of the wing disc. Rather, it is the level of expression and not the pattern of expression that is important for both the rate of growth as well as the rate of pattern maturation. Furthermore, a considerable amount of growth can occur when myc function is removed over most of development. We also find that the level of dMyc expression is regulated by the Fat signaling pathway in medial regions which is dependent on its downstream effector Dachs. Boundaries of different levels of the upstream regulators of Fat, Ds and Fj, can induce dMyc expression, but their endogenous expression patterns do not affect dMyc expression. In addition, we find that one of the upstream regulators of the Fat signaling pathway, Dachsous, also acts in parallel with Fat to expand dMyc regional regulation. Ultimately our work indicates that Fat signaling is one of many inputs into regulation of dMyc expression, and dMyc is one of many targets of the Fat signaling pathway responsible for growth regulation.

Indexing (document details)
Advisor: Johnston, Laura A.
School: Columbia University
School Location: United States -- New York
Source: DAI-B 72/04, Dissertation Abstracts International
Subjects: Genetics
Keywords: Drosophila myc, Expression pattern, Growth regulator, Size regulation, Wing growth
Publication Number: 3442850
ISBN: 9781124478913
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