Dissertation/Thesis Abstract

Overall Survival of Stage IIIB Non-Small Cell Lung Cancer Patients Utilizing Various Treatment Modalities
by Brewer, Connie, Ph.D., Northcentral University, 2011, 102; 3442985
Abstract (Summary)

Stage IIIB non-small cell lung cancer (NSCLC) marks the beginning of metastasis and represents a critical turning point in terms of patient survival. Varying methods of treatment have led to an accumulation of knowledge that can be problematic for both doctors and patients to decipher when making crucial judgments regarding the efficacy of treatment options. This research examined current literature and various treatment options using a meta-analysis and an independent samples t-test to compare differences in median survival rates. Pertinent data published over a 20 year period encompassing 32,313 patients diagnosed with Stage IIIB NSCLC was summarized in this research. The studies tested in the meta-analysis of this data included varying sample sizes so weighting according to sample size was performed on all outcome measures. The results of the testing indicated that chemoradiotherapy produced the greatest median survival rate (14.13 months), radiation (11.04 months), chemotherapy (7.76 months), and palliative care (4.67 months) when treating patients diagnosed with Stage IIIB NSCLC. This research compiled and analyzed data from previous studies to assist patients and physicians in reaching succinct conclusions as to which treatment modality or combination of modalities is the best treatment for each individual diagnosed with Stage IIIB NSCLC. Additional immunotherapy studies, research trials focused specifically on Stage IIIB NSCLC, and further exploration into the field of genomics, would be desirable tactics to employ in combating this disease that still yields such a poor length of survival regardless of whatever treatment modality is chosen.

Indexing (document details)
Advisor: Courts, Bari
School: Northcentral University
School Location: United States -- Arizona
Source: DAI-B 72/04, Dissertation Abstracts International
Subjects: Health care management, Oncology
Keywords: Cancer survival, Chemotherapy, Lung cancer, Palliative care, Radiotherapy
Publication Number: 3442985
ISBN: 9781124483672
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