Dissertation/Thesis Abstract

The temporal relationship of B-cell activating factor to human leukocyte antigen-specific antibodies
by Idica, Adam Kekoa Yuk Wo, M.S., California State University, Dominguez Hills, 2011, 42; 1489987
Abstract (Summary)

Human Leukocyte Antigen Antibodies (HLA-Ab) generated by transplant patients are the primary cause of chronic allograft rejection. B-cell activating factor in serum (sBAFF) is a B-cell differentiation and maturation cytokine that might be a biomarker for HLA-Ab production. A new sBAFF detection assay was developed and used to test a total of 139 serum samples from 17 non-sensitized male, 18 transfusion, and 21 kidney transplant patients. sBAFF was correlated with HLA-Ab production; non-sensitized males with low HLA-Ab had an average sBAFF level of 48,441 pg/mL versus 183,975 pg/mL for highly-sensitized transfusion patients (p<0.0001). Temporal analysis between sBAFF and HLA-Ab supports a lag effect where a rise in sBAFF precedes a rise in average HLA-Ab by 10 days and a rise in donor-specific HLA antibody by 19 days. Our findings suggest that sBAFF levels may be predictive of imminent HLA-Ab production and may facilitate earlier and more effective treatment of HLA-Ab.

Indexing (document details)
Advisor: Terasaki, Paul I.
School: California State University, Dominguez Hills
School Location: United States -- California
Source: MAI 49/04M, Masters Abstracts International
Subjects: Biology, Immunology
Publication Number: 1489987
ISBN: 978-1-124-47229-4
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