The development of advanced wound-dressing materials is an emerging field of materials chemistry that exploits the tunable surface properties of inorganic materials to modulate the intrinsic coagulation response. Inorganic materials have a long history of use as implantable biomaterials where a key component of biocompatibility is the prevention of thrombus formation at the surface of the material. In contrast, the use of inorganic materials as advanced wound-dressings is a recent development that requires blood clot initiation to occur rapidly on the material surface. While inorganic hemostatic agents are highly effective at controlling external hemorrhage, little is known about their mechanism of action and improvement of these agents is guided primarily by trial and error. The goals of our research are to identify the materials properties that are central to eliciting a procoagulant response and to use these insights for the rational design of both pro- and anticoagulant surfaces.
We have conducted a fundamental investigation into the influence of materials properties on the intrinsic pathway of coagulation, and have identified the properties that are necessary to elicit a procoagulant response. The materials studied were thoroughly characterized with respect to their physical properties and rheological studies were used to assess the blood clotting response in vitro. Our results indicate that inorganic oxide surface potential, protein-accessible surface area, particle morphology, and ion-exchange properties all have a profound influence on blood clot initiation. Preliminary studies on the influence of these variables on the chemistry of the blood clotting cascade have been made and will be described. By taking a systematic approach to characterizing the blood-materials interface, we have been able to develop superior hemostatic agents and continue to work toward a more detailed understanding of the enzymatic and cellular response to inorganic surfaces.
|Advisor:||Stucky, Galen D.|
|Commitee:||Han, Song-I, Waite, J. Herbert|
|School:||University of California, Santa Barbara|
|School Location:||United States -- California|
|Source:||DAI-B 72/01, Dissertation Abstracts International|
|Subjects:||Inorganic chemistry, Physical chemistry|
|Keywords:||Blood clots, Metal oxides|
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