Dissertation/Thesis Abstract

BP1 upregulates twist, a trigger of the epithelial to mesenchymal transition (EMT), which may lead to metastasis in breast cancer
by Hwang, Bin-Jin, M.S., The George Washington University, 2010, 96; 1480890
Abstract (Summary)

In previous research, BP1 appears to be associated with metastasis, shown by immunostaining on 46 samples of inflammatory breast cancer (as well as matched lymph nodes in 9 metastatic cases); all cases were BP1 positive. Now we suggest that BP1 induces breast cancer cells to undergo the epithelial to mesenchymal like transition (EMT). EMT, a process in which cancer cells lose their epithelial features and gain mesenchymal markers, enables tumor cells to become more invasive and migratory, and can lead to metastasis. BP1 upregulate Twist, a basic helix-loop-helix (bHLH) transcription factor which triggers EMT. Twist is well known for initiation of EMT in various cancers. We found that BP1 can upregulate Twist expression in two breast cancer cell lines, MCF-7 and HS578T, and induce EMT, resulting in increased migratory ability. On the other hand, exogenous BP1 can also increase Twist expression and migration ability of cancer cell lines, indicating that BP1 might be able to induce EMT in both a paracrine and endogenous manner.

Indexing (document details)
Advisor: Berg, Patricia E.
Commitee: Vanderhoek, Jack
School: The George Washington University
Department: Biochemistry and Molecular Biology
School Location: United States -- District of Columbia
Source: MAI 49/01M, Masters Abstracts International
Source Type: DISSERTATION
Subjects: Molecular biology, Cellular biology
Keywords: Breast cancer, Epithelial to mesenchymal transition, Homeobox genes, Metastasis
Publication Number: 1480890
ISBN: 9781124202921
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