Dissertation/Thesis Abstract

Molecular characterization of a subset of KRAB-ZFPs
by Chamoun, Alain, M.S., Florida Atlantic University, 2010, 82; 1485665
Abstract (Summary)

There are approximately 20,000 genes in the human genome. Around 2% of these genes code for transcriptional repressors known as KRAB-ZFPs. It is already known that Zinc-Finger Proteins contain two main functional domains at either end of the polypeptide. In today's database, you will find a KRAB (Kruppell-associated Box) domain at one end and a tandem array of Zinc-finger repeats at the other end. The carboxyl terminal tandem Zinc-finger repeats function as sequence-specific DNA-binding domains. The amino terminal KRAB domain serves as a repressor domain, which will recruit a co-repressor termed KAP-1 (KRAB Associated Protein-1). Located in between these two domains is a region of uncharacterized DNA referred to as the "Linker Region". This thesis will explore the DNA-binding domains of 6 known KRAB-ZFPs, as well as utilize the linker regions to derive an evolutionary history for this superfamily.

Indexing (document details)
Advisor: Ayyanathan, Kasirajan
School: Florida Atlantic University
School Location: United States -- Florida
Source: MAI 49/01M, Masters Abstracts International
Subjects: Molecular biology, Cellular biology, Bioinformatics
Publication Number: 1485665
ISBN: 978-1-124-14899-1
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