Parathyroid hormone-related protein (PTHrP) is expressed in many tissues and is often enriched in cancers. Tissue reaction to PTHrP varies as it is expressed as multiple isoforms, undergoes peptide processing, and has selective trafficking. PTHrP is secreted via a pre-pro -36 to -1 amino acid portion and interacts with extracellular receptors, including parathyroid hormone receptor 1 (PTH1R). PTHrP is also present within the cell and shuttles into and out of the nucleus via a nuclear localization signal (NLS) and a nuclear export signal (NES). Patients diagnosed with non-small cell lung carcinomas that express PTHrP, experience higher survival rates. PTHrP’s benefits in non-small cell lung cancer may result from its previously demonstrated anti-proliferative effects. Because of PTHrP’s highly intricate actions, its site of inhibitory action on proliferation is not known.
|Advisor:||Hastings, Randolph H.|
|Commitee:||Aroian, Raffi V., David, Michael|
|School:||University of California, San Diego|
|School Location:||United States -- California|
|Source:||MAI 48/06M, Masters Abstracts International|
|Subjects:||Molecular biology, Cellular biology|
|Keywords:||Adenocarcinoma, Cancer, Extracellular, Parathyroid-related hormone|
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