Dissertation/Thesis Abstract

The role of interleukin-19 in interleukin-10 production by regulatory macrophages
by Yahil, Ron Jonathan, M.S., University of Maryland, College Park, 2010, 55; 1478135
Abstract (Summary)

Interleukin-19 (IL-19) is a recently discovered member of the IL-10 family of Class II cytokines. Although it is known to be secreted by monocytes and has been associated with various models of disease, the biological function of IL-19 remains largely unknown. IL-19 does share many important characteristics with IL-10. Because of this, we hypothesized that IL-19 may be regulated in a manner similar to IL-10, and may provide insight into the molecular mechanism of IL-10 regulation. In addition, IL-19 has been reported to increase IL-10 production in monocytes, and we theorized that it may be able to do the same in macrophages. Like IL-10, IL-19 is expressed in regulatory macrophages. Also, IL-19 is itself able to increase IL-10 production in regulatory macrophages, and the mechanism is independent of ERK phosphorylation. This work suggests that IL-19 can play a central role in the anti-inflammatory processes of IL-10.

Indexing (document details)
Advisor: Mosser, David M.
Commitee: DeStefano, Jeffrey, McIver, Kevin
School: University of Maryland, College Park
Department: Cell Biology & Molecular Genetics
School Location: United States -- Maryland
Source: MAI 48/06M, Masters Abstracts International
Source Type: DISSERTATION
Subjects: Molecular biology, Cellular biology, Immunology
Keywords: Cytokines, Inflammation, Interleukin-10, Interleukin-19, MAP kinase, Macrophage
Publication Number: 1478135
ISBN: 9781124076720