Dissertation/Thesis Abstract

Extracellular matrix proteins: Implications for angiogenesis
by Williams, Kent Edward, M.S., Indiana State University, 2010, 65; 1476659
Abstract (Summary)

The extracellular matrix (ECM) is an essential requirement for maintaining permanent shape and rigidity in multicellular organisms. The ECM serves two main functions: scaffolding and signaling. Insoluble collagen and soluble proteoglycans, glycosaminoglycans (GAGs), and glycoproteins allow for water retention and flexibility. The signaling role of the ECM is essential for a multitude of events including vascular development and angiogenesis. Via interactions with vascular endothelial cells, proteins of the ECM can induce or repress angiogenesis.

Indexing (document details)
Advisor: Albig, Allan R.
Commitee: Ghosh, Swapan K., Hews, Diana K.
School: Indiana State University
Department: Biology
School Location: United States -- Indiana
Source: MAI 48/05M, Masters Abstracts International
Subjects: Molecular biology, Cellular biology
Keywords: Angiogenesis, Extracellular matrix, Lumican, Morpholino, Zebrafish
Publication Number: 1476659
ISBN: 9781124015989
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