The extracellular matrix (ECM) is an essential requirement for maintaining permanent shape and rigidity in multicellular organisms. The ECM serves two main functions: scaffolding and signaling. Insoluble collagen and soluble proteoglycans, glycosaminoglycans (GAGs), and glycoproteins allow for water retention and flexibility. The signaling role of the ECM is essential for a multitude of events including vascular development and angiogenesis. Via interactions with vascular endothelial cells, proteins of the ECM can induce or repress angiogenesis.
|Advisor:||Albig, Allan R.|
|Commitee:||Ghosh, Swapan K., Hews, Diana K.|
|School:||Indiana State University|
|School Location:||United States -- Indiana|
|Source:||MAI 48/05M, Masters Abstracts International|
|Subjects:||Molecular biology, Cellular biology|
|Keywords:||Angiogenesis, Extracellular matrix, Lumican, Morpholino, Zebrafish|
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