The Department of Veterans Affairs (VA) mandates human research protection program (HRPP) accreditation for all VA Medical Centers conducting research involving human participants. This descriptive nonexperimental study aimed to investigate possible methods for evaluating HRPP effectiveness by examining the relationship between number and types of human research studies and the Association of Human Research Protection Program's (AAHRPP) accreditation outcomes. Applying concepts from Patton's approach to utilization-focused program evaluation, the study was designed with the specific needs of the VA Office of Research and Development as the primary intended users. Data were collected from AAHRPP applications submitted by 90 VA HRPPs between February 2006 and September 2008 and reports generated by AAHRPP following VA HRPP site visits and AAHRPP Council on Accreditation evaluations. Of 87 VA HRPPs included in the analyses, 57% (n = 50) used IRBs within their own VA institutions, 38% (n = 33) used IRBs of affiliated universities, and 5% (n = 4) used IRBs of other VA HRPPs. Time to obtain full or qualified accreditation decisions ranged from 7 to 32 months (M = 11 months, Mdn = 11.15, SD = 4.72660).
There were no statistically significant associations (p < 0.05) between length of time to obtain accreditation or number of AAHRPP elements reported as met and number of studies, percentage of studies initially reviewed by convened IRBs, and percentage of sponsored studies. A strong relationship existed between type of IRB used by the VA HRPP and length of time to obtain HRPP accreditation (eta2 = 0.163). Multiple regression results were statistically significant in predicting time required to obtain AAHRPP accreditation (n = 86; adj R 2 = 0.24, p < 0.0001), but only one variable (use of an affiliate IRB) significantly contributed to the model. This is not unexpected since fewer numbers of elements are evaluated in HRPPs using IRBs of organizations obtaining separate AAHRPP accreditation. Continued studies are needed to provide further direction for development of valid measurable indicators of AAHRPP accreditation and HRPP effectiveness.
|School:||University of Arkansas for Medical Sciences|
|School Location:||United States -- Arkansas|
|Source:||DAI-B 71/06, Dissertation Abstracts International|
|Subjects:||Medical Ethics, Health sciences, Health care management|
|Keywords:||Accreditation, Department of Veterans Affairs, Human research, Human research protection program, Institutional review board|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be