Research shows that HIV/AIDS stigma impacts the prevention and care of HIV. This study examines how HIV/AIDS stigma impacts the lives of HIV-positive Latinos residing along the United States-Mexico border. The present study utilizes a semi-structured interview protocol with seropositive Latinos in El Paso, Texas and San Ysidro, California. Thirty-three interviews were conducted in the spring of 2002. Atlas.ti 5.6 was utilized for qualitative analysis of transcripts. Over half of respondents felt stigmatized or discriminated against as a result of their seropositive status. HIV status was found to strain relations with family and friends, as well as underpin discrimination from care providers. A reluctance to use condoms based on machismo was also found. Social norms against Latinas initiating condom use was found to prevent Latinas from exerting agency in protecting themselves against HIV and other sexually transmitted infections.