Part A. Aminophosphonates have been studied and characterized due to their biological activity such as enzyme inhibitors, antibiotics, peptide mimics, herbicides, and pharmacological agents. In our efforts to prepare organophosphorus compounds to be employed as novel inhibitors for butyrylcholinesterase, we became interested in exploring other Lewis acids as potential catalysts for the Kabachnik-Fields reaction. Here in we report that SnCl2, among other Sn(II) compounds, is an efficient catalyst for the synthesis of α-aminophosphonates in a one-pot reaction under solvent free conditions.
Part B. Alzheimer disease is associated with a significant decrease of acetylcholine that correlates directly with loss of cognitive functions. Current clinical protocols increase the levels of acetylcholine by inhibiting acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Previous in vitro studies have shown that dialkyl phenyl phosphates (DAPPs) are very selective inhibitors towards BChE. In this work, several "second generation" organophosphorus compounds were synthesized to study inhibitor structural effects on BChE inhibition.
|School:||California State University, Long Beach|
|School Location:||United States -- California|
|Source:||MAI 48/02M, Masters Abstracts International|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be