Dissertation/Thesis Abstract

Injury-induced cell proliferation in brain repair and recovery of function
by Drumheller, Kristin, M.A., California State University, Long Beach, 2009, 72; 1472290
Abstract (Summary)

The discovery that stem cells give birth to new glia and neurons in the adult brain provides a potential mechanism for structural repair and recovery of function following injury or disease. This study investigated injury-induced cell proliferation in the hippocampus and neighboring stem cell rich subventricular zone (SVZ). Following training on a one trial associative memory task, birds received a bilateral hippocampal lesion or sham surgery then three injections of BrdU (mitotic marker). A subset was perfused 24 hours later to assess short-term cell birth, while others continued behavioral assessment for six additional weeks. Hippocampal lesions resulted in an initial loss of spatial learning abilities, subsequent recovery of spatial learning by the seventh week post-lesion, and significantly more newly born cells in the hippocampus and SVZ. Such findings could indicate that injury-induced cell proliferation and incorporation underlies structural repair and recovery of function.

Indexing (document details)
Advisor: Lee, Diane W.
School: California State University, Long Beach
School Location: United States -- California
Source: MAI 48/02M, Masters Abstracts International
Subjects: Psychobiology, Behavioral psychology, Physiological psychology
Publication Number: 1472290
ISBN: 978-1-109-47230-1
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