The discovery that stem cells give birth to new glia and neurons in the adult brain provides a potential mechanism for structural repair and recovery of function following injury or disease. This study investigated injury-induced cell proliferation in the hippocampus and neighboring stem cell rich subventricular zone (SVZ). Following training on a one trial associative memory task, birds received a bilateral hippocampal lesion or sham surgery then three injections of BrdU (mitotic marker). A subset was perfused 24 hours later to assess short-term cell birth, while others continued behavioral assessment for six additional weeks. Hippocampal lesions resulted in an initial loss of spatial learning abilities, subsequent recovery of spatial learning by the seventh week post-lesion, and significantly more newly born cells in the hippocampus and SVZ. Such findings could indicate that injury-induced cell proliferation and incorporation underlies structural repair and recovery of function.
|Advisor:||Lee, Diane W.|
|School:||California State University, Long Beach|
|School Location:||United States -- California|
|Source:||MAI 48/02M, Masters Abstracts International|
|Subjects:||Psychobiology, Behavioral psychology, Physiological psychology|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be