Pesticides and polycyclic aromatic hydrocarbons pose detrimental health effects to humans dependent upon levels of exposure and toxicity. Organochlorines, organophosphates, and synthetic pyrethroids are used agriculturally and within households, throughout the world, to minimize pests. The presence of OCs, OPs, and PAHs was examined in house dust from eighteen households located in Nepal. An area of floor from each home was marked and wiped for dust samples. The samples were solvent extracted and analyzed using gas chromatography/electron capture detector (GC/ECD) to quantify OCs, and gas chromatography/mass spectrometry (GC/MS) to quantify OPs and PAHs. Total carcinogenic PAHs ranged from 119 ng/m² to 4110 ng/m², total OCs ranged from undetectable amounts to 11858 ng/m², and total OPs ranged from undetected amounts to 537 ng/m². The data provides information regarding amounts of PAHs, OCs, and OPs within the households sampled, and a basis for comparison between Nepal and other regions around the world.