Cancer is considered a contraindication for osteopathic manipulative treatments, including lymphatic pump techniques (LPT). However, studies from our laboratory demonstrate that LPT improves immune surveillance, potentially enhancing protection against tumor development and metastasis. To test whether LPT reduces lung tumors, rats were injected intravenously with MADB106. Twenty-four hours following tumor injection, rats received no treatment, sham, or LPT for seven days. On day eight, lung tumors and immune cell activities were measured. LPT reduced pulmonary tumors approximately 30%, did not promote lung tumor dissemination into other tissues and increased pulmonary leukocytes. LPT may have enhanced pulmonary trafficking of leukocytes with anti-tumor activities, inhibiting lung tumor growth; however, mechanisms by which LPT reduced lung tumors are under investigation.
|Advisor:||Hodge, Lisa Michelle|
|Commitee:||Caffrey, James, Jones, Harlan, Mathew, Porunelloor|
|School:||University of North Texas Health Science Center at Fort Worth|
|Department:||Microbiology and Immunology|
|School Location:||United States -- Texas|
|Source:||MAI 48/03M, Masters Abstracts International|
|Keywords:||Cancer, Cancer treatment, Fisher 344, Immunity, Lymphatic pump treatment, MADB106|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be