Dissertation/Thesis Abstract

Lymphatic pump treatment enhances pulmonary immunity and inhibits solid tumor formation in the lung
by Pedrueza, Mayela, M.S., University of North Texas Health Science Center at Fort Worth, 2009, 53; 1473681
Abstract (Summary)

Cancer is considered a contraindication for osteopathic manipulative treatments, including lymphatic pump techniques (LPT). However, studies from our laboratory demonstrate that LPT improves immune surveillance, potentially enhancing protection against tumor development and metastasis. To test whether LPT reduces lung tumors, rats were injected intravenously with MADB106. Twenty-four hours following tumor injection, rats received no treatment, sham, or LPT for seven days. On day eight, lung tumors and immune cell activities were measured. LPT reduced pulmonary tumors approximately 30%, did not promote lung tumor dissemination into other tissues and increased pulmonary leukocytes. LPT may have enhanced pulmonary trafficking of leukocytes with anti-tumor activities, inhibiting lung tumor growth; however, mechanisms by which LPT reduced lung tumors are under investigation.

Indexing (document details)
Advisor: Hodge, Lisa Michelle
Commitee: Caffrey, James, Jones, Harlan, Mathew, Porunelloor
School: University of North Texas Health Science Center at Fort Worth
Department: Microbiology and Immunology
School Location: United States -- Texas
Source: MAI 48/03M, Masters Abstracts International
Source Type: DISSERTATION
Subjects: Immunology, Oncology
Keywords: Cancer, Cancer treatment, Fisher 344, Immunity, Lymphatic pump treatment, MADB106
Publication Number: 1473681
ISBN: 9781109580549
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