Dissertation/Thesis Abstract

Evaluation of D3 dopamine receptor selective compounds on L-dopa dependent abnormal involuntary movements in rats
by Riddle, Lindsay, M.S., University of North Texas Health Science Center at Fort Worth, 2009, 85; 1459925
Abstract (Summary)

Parkinson's Disease (PD) is caused by the degeneration of dopaminergic neurons in the midbrain that innervate the striatum. Parkinsonian motor symptoms are alleviated by administration of levodopa, but overtime this treatment can induce abnormal involuntary movements (AIMS). The hypothesis of this thesis is that D3 dopamine receptor selective compounds can attenuate the L-dopa induced AIMs in unilaterally lesioned rats. The severity of L-dopa induced rodent AIMs was significantly reduced by the acute administration of the D3 receptor selective agonist PG01042. These results suggest a dopaminergic pharmacotherapeutic approach may provide an effective way of treating abnormal involuntary movements in PD patients treated with L-dopa.

Indexing (document details)
Advisor: Luedtke, Robert R.
Commitee: Dillon, Glenn, Hodge, Lisa, Jones, Harlan, Yang, Shaohua
School: University of North Texas Health Science Center at Fort Worth
Department: Microbiology and Immunology
School Location: United States -- Texas
Source: MAI 47/03M, Masters Abstracts International
Subjects: Pharmacology
Keywords: Abnormal involuntary movements, Dopaminergic, Dyskinesia, L-dopa, Parkinson's disease
Publication Number: 1459925
ISBN: 978-0-549-90566-0
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