Parkinson's Disease (PD) is caused by the degeneration of dopaminergic neurons in the midbrain that innervate the striatum. Parkinsonian motor symptoms are alleviated by administration of levodopa, but overtime this treatment can induce abnormal involuntary movements (AIMS). The hypothesis of this thesis is that D3 dopamine receptor selective compounds can attenuate the L-dopa induced AIMs in unilaterally lesioned rats. The severity of L-dopa induced rodent AIMs was significantly reduced by the acute administration of the D3 receptor selective agonist PG01042. These results suggest a dopaminergic pharmacotherapeutic approach may provide an effective way of treating abnormal involuntary movements in PD patients treated with L-dopa.
|Advisor:||Luedtke, Robert R.|
|Commitee:||Dillon, Glenn, Hodge, Lisa, Jones, Harlan, Yang, Shaohua|
|School:||University of North Texas Health Science Center at Fort Worth|
|Department:||Microbiology and Immunology|
|School Location:||United States -- Texas|
|Source:||MAI 47/03M, Masters Abstracts International|
|Keywords:||Abnormal involuntary movements, Dopaminergic, Dyskinesia, L-dopa, Parkinson's disease|
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