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Dissertation/Thesis Abstract

Construction of a dual infection mechanism for HIV
by Piekarski, Joseph Matthew, M.S., University of Maryland, Baltimore County, 2009, 148; 1465379
Abstract (Summary)

In this work, we created three mathematical models to describe HIV infection. Our goal was to investigate the effectiveness of cell-to-cell infection via “virological synapses” through the designed models. The combination of cell-to-cell infection and free-floating virus mechanisms in mathematical models has not been investigated as of yet. We evaluated the two models using three statistical techniques, and decided to use a weighted summation of squares to compare our projected results to published experimental data. The analysis found that the addition of a cell-to-cell infection mechanism did not hinder the predictability of HIV markers for disease progression and showed cell-to-cell infection was most significant early on in infection. In our last model, we further investigated the mechanisms responsible for T cell depletion. Many theories have been published hypothesizing the cause of immune failure. These range from heightened activation of T cells, cytotoxic virions and the eventual destruction due to productive infection. In our model, we observed that the majority of cells die due to the direct result of infection.

Indexing (document details)
Advisor: Castellanos, Mariajose
Commitee: Frey, Douglas D., Good, Theresa
School: University of Maryland, Baltimore County
Department: Engineering, Chemical and Biochemical
School Location: United States -- Maryland
Source: MAI 47/06M, Masters Abstracts International
Subjects: Virology
Keywords: Cell-to-cell, Dual infection, Dynamics, HIV, T cells
Publication Number: 1465379
ISBN: 978-1-109-18752-6
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