Dissertation/Thesis Abstract

BMI-1 expression inversely correlates with differentiation but not clinical outcome or CDKN2a expression in Ewing sarcoma family of tumors
by van Doorninck, John Anthony, M.S., University of Southern California, 2009, 39; 1467574
Abstract (Summary)

Ewing sarcoma family tumors (ESFT) are highly undifferentiated bone and soft tissue tumors that primarily affect children. Metastatic disease at diagnosis portends a worse prognosis and remains the only reliable predictor of outcome. The polycomb protein BMI-1 is associated with worse clinical outcome in some human cancers. This study evaluates the clinical and biologic significance of BMI-1 expression in ESFT.

Using immunohistochemical analysis, 80% of ESFT were found to robustly express BMI-1 in all tumor cells, while 15% lacked BMI-1 expression. Analysis of 79 tumors revealed no association between BMI-1 and clinical presentation, outcome, loss of p16 or mutation of p53. Significantly, however, BMI-1 levels were highly inversely correlated with markers of neural crest differentiation. Together these findings demonstrate that ESFT cells nearly universally express BMI-1 and suggest that high-level expression of BMI-1 underlies the highly undifferentiated phenotype that characterizes this tumor family.

Indexing (document details)
Advisor: Seeger, Robert
Commitee: Aldrovandi, Grace, Sposto, Richard
School: University of Southern California
Department: Preventive Medicine (Health Behavior Research)
School Location: United States -- California
Source: MAI 47/06M, Masters Abstracts International
Subjects: Neurosciences, Medicine, Pathology
Keywords: BMI-1, CDKN2a, Ewing sarcoma, Expression profiling, Prognosis, Stem cell
Publication Number: 1467574
ISBN: 978-1-109-29530-6
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