Ewing sarcoma family tumors (ESFT) are highly undifferentiated bone and soft tissue tumors that primarily affect children. Metastatic disease at diagnosis portends a worse prognosis and remains the only reliable predictor of outcome. The polycomb protein BMI-1 is associated with worse clinical outcome in some human cancers. This study evaluates the clinical and biologic significance of BMI-1 expression in ESFT.
Using immunohistochemical analysis, 80% of ESFT were found to robustly express BMI-1 in all tumor cells, while 15% lacked BMI-1 expression. Analysis of 79 tumors revealed no association between BMI-1 and clinical presentation, outcome, loss of p16 or mutation of p53. Significantly, however, BMI-1 levels were highly inversely correlated with markers of neural crest differentiation. Together these findings demonstrate that ESFT cells nearly universally express BMI-1 and suggest that high-level expression of BMI-1 underlies the highly undifferentiated phenotype that characterizes this tumor family.
|Commitee:||Aldrovandi, Grace, Sposto, Richard|
|School:||University of Southern California|
|Department:||Preventive Medicine (Health Behavior Research)|
|School Location:||United States -- California|
|Source:||MAI 47/06M, Masters Abstracts International|
|Subjects:||Neurosciences, Medicine, Pathology|
|Keywords:||BMI-1, CDKN2a, Ewing sarcoma, Expression profiling, Prognosis, Stem cell|
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