Dissertation/Thesis Abstract

Genotoxic impurity analysis in pharmaceuticals
by Janson, Matthew Austin, M.S., University of Southern California, 2009, 79; 1473496
Abstract (Summary)

This review paper covers the analytical methods used to monitor genotoxic impurities. Specifically, the impurities discussed here contain hydrazine, nitro, arylamine or aldehyde functional groups as found in pharmaceuticals. These genotoxic impurities can come from many places including starting materials, reagents, intermediates, solvents or unwanted side reactions of the active pharmaceutical ingredient (API) synthetic process that get carried over into the final product. In addition, the API itself can decompose to form genotoxic impurities or they can form in the drug product by reaction between excipients or containers and the API. The control of these potent impurities is critical which are generally monitored at very low levels in the ppm and ppb range. This poses many challenges on the analytical methods to achieve high sensitivity as well as separation of the impurities from the sample matrix for selectivity.

Indexing (document details)
Advisor: Shen, Wei-Chiang
Commitee: Okamoto, Curtis, Wang, Clay
School: University of Southern California
Department: Pharmaceutical Sciences
School Location: United States -- California
Source: MAI 48/03M, Masters Abstracts International
Source Type: DISSERTATION
Subjects: Analytical chemistry
Keywords: Analysis, Genotoxic, Impurity, Pharmaceutical, Review
Publication Number: 1473496
ISBN: 978-1-109-56353-5
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