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Dissertation/Thesis Abstract

Are the GCF levels of MCP-1 and RANTES elevated in peri-partum women with periodontitis as compared to healthy controls?
by Martin, E. Ashley, M.S., The University of North Carolina at Chapel Hill, 2009, 49; 1463861
Abstract (Summary)

The study objective was to compare levels of gingival crevicular fluid (GCF), MCP-1 and RANTES in peri-partum women with periodontal disease to healthy controls. This is secondary analysis of Oral Conditions and Pregnancy (OCAP), a case-control study. Subjects (N=80) were stratified post-hoc based on periodontal status. An oral exam was performed within 72 hours after delivery. Cases (n=42) had moderate to severe/periodontitis (≥15 sites with PD≥ 4mm). Controls (n=38) had a healthy periodontium (PD≤ 3mm). Pregnancy history was obtained through charts and interviews. Statistical tests included chi-square and t-test. Groups were balanced for age (p=0.57) but not race. Cases and controls were 17% and 82% Caucasian, respectively (p<0 .0001). There were no statistically significant (SS) differences between cases and controls. MCP-1 and RANTES were lower in cases than controls although not SS. There is no significant difference between MCP-1 and RANTES levels in women with periodontitis compared with healthy controls.

Indexing (document details)
Advisor: Wilder, Rebecca S.
Commitee: Boggess, Kim, Jared, Heather
School: The University of North Carolina at Chapel Hill
Department: Dentistry: Dental Hygiene
School Location: United States -- North Carolina
Source: MAI 47/05M, Masters Abstracts International
Subjects: Microbiology
Keywords: Low birth weight, Periodontal disease, Pregnancy, Preterm delievery
Publication Number: 1463861
ISBN: 978-1-109-11549-9
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