The aging process affects all mammals and is typically seen with a gradual decline in overall system functionality. This can affect organ and immune function, resulting in increased susceptibility to diseases such as cancer. There are many theories as to specific mechanisms of longevity; we investigate the neuroendocrine regulation of glucose utilization as a potential mediator. Animal models are valuable tools in our efforts to perform gerontological research. Increased lifespan in rodents and mice has been observed through calorie restriction and single mutations, such as Pit-/- and Proph1-/-. Our results in Snell dwarf mice suggest that the pituitary gland and adipose tissue are part of a neuroendocrine loop that lower the risk of cancer during aging by reducing the availability of glucose.
|Advisor:||Combs, Terry P.|
|Commitee:||Beck, Melinda, Clemmons, David, Coleman, Rosalind|
|School:||The University of North Carolina at Chapel Hill|
|School Location:||United States -- North Carolina|
|Source:||MAI 47/05M, Masters Abstracts International|
|Subjects:||Molecular biology, Nutrition, Medicine|
|Keywords:||Adiponectin, Cancer, Chromogranin, Dwarf mice, Glucose production, Longevity|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be