Dissertation/Thesis Abstract

The aging process deconstructed: Glucose production, cancer resistance and longevity
by Alderman, Jennifer McKee, M.S., The University of North Carolina at Chapel Hill, 2009, 42; 1464576
Abstract (Summary)

The aging process affects all mammals and is typically seen with a gradual decline in overall system functionality. This can affect organ and immune function, resulting in increased susceptibility to diseases such as cancer. There are many theories as to specific mechanisms of longevity; we investigate the neuroendocrine regulation of glucose utilization as a potential mediator. Animal models are valuable tools in our efforts to perform gerontological research. Increased lifespan in rodents and mice has been observed through calorie restriction and single mutations, such as Pit-/- and Proph1-/-. Our results in Snell dwarf mice suggest that the pituitary gland and adipose tissue are part of a neuroendocrine loop that lower the risk of cancer during aging by reducing the availability of glucose.

Indexing (document details)
Advisor: Combs, Terry P.
Commitee: Beck, Melinda, Clemmons, David, Coleman, Rosalind
School: The University of North Carolina at Chapel Hill
Department: Nutrition
School Location: United States -- North Carolina
Source: MAI 47/05M, Masters Abstracts International
Subjects: Molecular biology, Nutrition, Medicine
Keywords: Adiponectin, Cancer, Chromogranin, Dwarf mice, Glucose production, Longevity
Publication Number: 1464576
ISBN: 978-1-109-14959-3
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