Rapid development of antibacterial drug resistance is one of the most critical issues in the treatment of infectious diseases in many places over the world. In the past two decades, antimicrobial host defense peptides (AMPs) have been shown to exhibit broad-spectrum activity against a wide range of microorganisms including Gram-positive and negative bacteria, fungi and some viruses. With an understanding of the important role that antimicrobial host defense peptides play in preventing infections by microbial pathogens in many organisms, it has been proposed that these peptides might form a new class of clinically useful antimicrobials. My contributions to this effort include (i) comparing and studying the antimicrobial effect of various AMP scaffolds and analogs based on short cationic AMP peptides (RW)n sequences; (ii) determining the effect of various short linear AMPs, dendrimer AMP and AMP polymers against bacterial biofilm formation; (iii) designing and screening series of small libraries of 1,3,5-triazine derivatives that mimic short cationic antimicrobial peptides, which led to successful identification of several powerful antimicrobial agents. These results give insights to the potential application of AMPs and AMP derivatives as novel antibacterial and biofilm agents to overcome the increasing drug resistance among bacterial pathogens.
|Advisor:||Kallenbach, Neville R.|
|Commitee:||Abrams, William, Broyde, Suse, Goldberg, Burt, Vologodskii, Alex|
|School:||New York University|
|School Location:||United States -- New York|
|Source:||DAI-B 70/12, Dissertation Abstracts International|
|Keywords:||Antimicrobial peptides, Biofilms, Dendrimers, Peptide mimetics, Triazine|
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