With the aid of novel synthetic methodologies and new analytical techniques, studies on natural products opened a new era of pharmaceutical science. In many cases, these candidates are derivatives of the active compound of the natural product synthesis.
Octalactin A, a novel eight-membered lactone-containing natural product with potent cytotoxic properties, was isolated from marine bacterium, Pacifigorgia sp., which lives in association with a type of octacoral. Its isolation and structure determination were reported by Fenical and Clardy in 1991.1 In 1994, the first total synthesis of octalactin A was achieved by Buszek.2 The Buszek laboratory published another approach to octalactin A via the ring closing metathesis (RCM) method in 20023 and continued the research on the novel medium-ring libraries. The research presented in this thesis is focused on the synthesis of a speculative eight-membered lactam library inspired by octalactin A.
|Advisor:||Buszek, Keith R.|
|School:||University of Missouri - Kansas City|
|School Location:||United States -- Missouri|
|Source:||MAI 48/02M, Masters Abstracts International|
|Subjects:||Oncology, Organic chemistry|
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