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With the aid of novel synthetic methodologies and new analytical techniques, studies on natural products opened a new era of pharmaceutical science. In many cases, these candidates are derivatives of the active compound of the natural product synthesis.
Octalactin A, a novel eight-membered lactone-containing natural product with potent cytotoxic properties, was isolated from marine bacterium, Pacifigorgia sp., which lives in association with a type of octacoral. Its isolation and structure determination were reported by Fenical and Clardy in 1991.1 In 1994, the first total synthesis of octalactin A was achieved by Buszek.2 The Buszek laboratory published another approach to octalactin A via the ring closing metathesis (RCM) method in 20023 and continued the research on the novel medium-ring libraries. The research presented in this thesis is focused on the synthesis of a speculative eight-membered lactam library inspired by octalactin A.
Advisor: | Buszek, Keith R. |
Commitee: | |
School: | University of Missouri - Kansas City |
School Location: | United States -- Missouri |
Source: | MAI 48/02M, Masters Abstracts International |
Source Type: | DISSERTATION |
Subjects: | Oncology, Organic chemistry |
Keywords: | |
Publication Number: | 1472207 |
ISBN: | 978-1-109-46921-9 |