Dissertation/Thesis Abstract

Polymeric micro/nanofibers: Fabrication, aligned deposition, mechanical characterization, and biological applications
by Nain, Amrinder Singh, Ph.D., Carnegie Mellon University, 2007, 264; 3282365
Abstract (Summary)

Precise manufacturing of nanofibers is an essential bottom-up manufacturing technique in nano environment and polymeric micro/nanofibers offer several advantages over other materials. In this work, we have developed two techniques for repeatable fabrication of precisely aligned polymeric fibers of polystyrene (PS) and poly (methyl methacrylate) (PMMA) with diameters ranging from sub 50 nm to few microns and several millimeters in length. For the first time, dependency of properties of the fabricated micro/nanofibers on solution rheological properties and molecular weight are mapped in accordance with theoretical predictions. Mechanical properties of the deposited aligned fibers, as small as 34 nm in diameter, with fixed-fixed boundary conditions are characterized using state-of-the-art atomic force microscopy and electron microscopy. Resonance frequency measurements of the deposited fibers are in agreement with analytical models and are shown to estimate the Young's modulus of sub-micron fibers. Finally, Spinneret based Tunable Engineered Parameters (STEP) technique has been developed for fabricating single and multi-layer biomaterial scaffolds. Scaffolds are successfully seeded with mouse pluripotential cells for tissue engineering applications and the geometrical constraints of diverging fibers in single layer scaffolds and intersecting fibers (right angle) have provided new insights into cellular dynamics and the design of future aligned biomaterial scaffolds.

Indexing (document details)
Advisor:
Commitee:
School: Carnegie Mellon University
School Location: United States -- Pennsylvania
Source: DAI-B 68/09, Dissertation Abstracts International
Source Type: DISSERTATION
Subjects: Polymers, Mechanical engineering, Biophysics
Keywords: Aligned deposition, Microfibers, Nanofibers, Polystyrene
Publication Number: 3282365
ISBN: 9780549241768
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