Protein kinase C (PKC) is an archetypal mediator of cellular signaling. PKC consists of 10 Ser/Thr kinases that participate in a wide range of cellular processes, including proliferation, apoptosis, learning and memory, and cell migration. PKC signaling is controlled by lipid second messengers and protein scaffolding. For proper cellular PKC signaling, location and timing of activation are critical. Aberrant PKC signaling is known to occur in disease states, notably cancer. The goal of this thesis is to examine how spatial and temoral specificity are achieved in cellular PKC signaling, and how this regulation is altered in cancer. Understanding the nuances of PKC regulation in cells and mis-regulation in disease will undoubtedly inform efforts to therapeutically target this enzyme family.
|Commitee:||Field, Seth, Heller-Brown, Joan, Tsien, Roger, Webster, Nicholas|
|School:||University of California, San Diego|
|School Location:||United States -- California|
|Source:||DAI-B 70/08, Dissertation Abstracts International|
|Subjects:||Molecular biology, Biochemistry|
|Keywords:||Cancer, Diacylglycerol, Kinase, Protein kinase C, Scaffolds, Signaling|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be