The topographic projection of each thalamic nucleus to a unique set of cortical areas underlies the input specificity characterizing each sensory modality. Although the importance of the patterning of thalamic projections for normal cortical function has long been appreciated, the underlying developmental mechanisms remain largely unknown. The aim of my thesis was to identify some of the cellular and molecular cues patterning thalamocortical projections. First, I developed a novel technique to quantitatively study the topography of thalamocortical axons in vivo. Second, I showed that a single gradient of Netrin-1 controls the rostro-caudal topography of thalamocortical axons inside the ventral telencephalon through both attractive and repulsive mechanisms. Third, I confirm that an interaction between corticofugal and thalamic axons inside the VTel acts as a topographic cue for caudal thalamic axons, thus providing the first experimental evidence of the 'handshake hypothesis.'
|Commitee:||Anton, Eva, Crews, Steve, Deshmukh, Mohanish, Pevny, Larysa|
|School:||The University of North Carolina at Chapel Hill|
|School Location:||United States -- North Carolina|
|Source:||DAI-B 69/04, Dissertation Abstracts International|
|Subjects:||Molecular biology, Neurology|
|Keywords:||Axon guidance, Internal capsule, Netrin-1, Thalamocortical axon, Thalamocortical projections, Thalamus, Topography, Ventral telencephalon|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be