Dissertation/Thesis Abstract

Frontal alpha electroencephalography (EEG) asymmetry as a risk factor for pre-menstrual dysphoric disorder (PMDD); a psychophysiological and family history approach
by Accortt, Eynav Elgavish, Ph.D., The University of Arizona, 2009, 87; 3366223
Abstract (Summary)

Premenstrual dysphoric disorder (PMDD) is a severe dysphoric form of premenstrual syndrome (PMS) that is included as a diagnosis for further study in the DSM-IV (APA, 2000). A primary aim of the present study was to characterize the co-occurrence of PMDD and major depression, in a sample that spans the entire range of depressive severity. The range included non-depressed controls, women meeting criteria for dysthymia, and women meeting criteria for current Major Depressive Disorder (MDD). Co-occurrence of MDD and PMDD were only statistically significant when considering Lifetime MDD. Resting frontal electroencephalographic (EEG) asymmetry has been hypothesized to tap a diathesis toward depression or other emotion-related psychopathology. Another primary aim was to assess Frontal EEG asymmetry in college women who meet criteria for Pre-Menstrual Dysphoric Disorder (n = 25) and 25 matched controls. Participants were assessed four times in a two week period. Women reporting low premenstrual dysphoric symptomatology exhibited greater relative left frontal activity at rest than did women high in premenstrual dysphoric symptomatology. These results are consistent with a diathesis–stress model for premenstrual dysphoric symptomatology. A secondary aim was to assess whether individuals with PMDD or menstrual related mood variability, but no current diagnosis of depression, have an increased family history of depression. Promising evidence of a relationship between family history of MDD and a likelihood of PMDD was discovered. A trend was found for Spectrum PMDD women: a higher rate of Family History of MDD (36%) than non PMDD women (19.6%). Ideally, resting frontal electroencephalographic (EEG) asymmetry could help us learn more about the etiology of depression and hormonal-related depression specifically, and test whether they may share etiological factors.

Indexing (document details)
Advisor: Allen, John J.
Commitee: Bootzin, Richard, Kaszniak, Alfred, Sbarra, David
School: The University of Arizona
Department: Psychology
School Location: United States -- Arizona
Source: DAI-B 70/07, Dissertation Abstracts International
Subjects: Clinical psychology, Physiological psychology
Keywords: Depression, Diathesis-stress, Family history, Frontal alpha electroencephalography (EEG) asymmetry, Pre-menstrual dysphoric disorder, Risk factors
Publication Number: 3366223
ISBN: 978-1-109-27039-6
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