Dissertation/Thesis Abstract

Seeking mRNA methylation inhibitors as antiviral agents
by Li, Weikuan, Ph.D., Auburn University, 2008, 159; 3333182
Abstract (Summary)

Aristeromycin and neplanocin A are two examples of potent S-adenosylhomocysteine hydrolase inhibitors. As a consequence, they show significant broad-spectrum antiviral activity, however, their clinical potential is limited by toxicity, which is associated with phosphorylation at their 5'-hydroxyl groups. 5'-Noraristeromycin has been found to exhibit wide-spectrum antiviral activity with reduced toxicity due to its inability to form the corresponding nucleotide. To explore new antiviral agents retaining aristeromycin-based activity while reducing undesired toxicity, 5'-fluoro-5'-deoxyaristeromycin (1), 4'-fluoro-4'-deoxynoraristeromycin (2), 3,7-dideazaaristeromycin (3) and 3,7-dideazanoraristeromycin (4) were synthesized. Compounds 1 and 2 showed moderate activity against measles but were inactive in other antiviral assays. Compounds 3 and 4 exhibited no significant activity against all viruses tested.

Another member of the adenosine (Ado) set is sinefungin (5), which is a naturally occurring analog of S-adenosyl-L-homocysteine (AdoHcy) or S-adenosylmethionine (AdoMet). The wide-spectrum biological activities (anti-fungal, anti-virus, anti-bacteria and anti-malarial) are associated with its inhibition of AdoMet dependent methyltransferases. The application of sinefungin is limited by its toxicity. A convenient synthesis of sinefungin and related compounds (6, 7 and 8) was developed.

Indexing (document details)
Advisor: Schneller, Stewart W.
Commitee:
School: Auburn University
School Location: United States -- Alabama
Source: DAI-B 69/10, Dissertation Abstracts International
Source Type: DISSERTATION
Subjects: Organic chemistry
Keywords: Antiviral, Aristeromycin, Carbocyclic nucleosides, Methylation inhibitors, mRNA methylation
Publication Number: 3333182
ISBN: 978-0-549-85763-1
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