The main themes of the work comprising this dissertation are (i) endogenous regulators of microtubule function, such as tau, generate distinct microtubule structures to regulate the critical processes of neuronal development and maintenance such as kinesin-based transport (Chapter I), and (ii) treatment of microtubules with pharmacological agents such as paclitaxel and benomyl also generate structurally and functionally diverse microtubules (Chapter II), whose complex behavioral signatures can be detected and characterized by enhanced imaging and high-level statistical analyses to reveal novel mechanistic insights (Chapter III).
|Advisor:||Feinstein, Stuart C.|
|School:||University of California, Santa Barbara|
|School Location:||United States -- California|
|Source:||DAI-B 70/02, Dissertation Abstracts International|
|Subjects:||Molecular biology, Neurosciences, Cellular biology|
|Keywords:||Kinesin, Microtubules, Neurodegenerative disease, Neuronal development, Tau protein|
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