Dissertation/Thesis Abstract

Modulation of microtubule structure and function by tau and kinesin: Implications for neuronal development and neurodegenerative disease
by Peck, Austin James, Ph.D., University of California, Santa Barbara, 2008, 200; 3347590
Abstract (Summary)

The main themes of the work comprising this dissertation are (i) endogenous regulators of microtubule function, such as tau, generate distinct microtubule structures to regulate the critical processes of neuronal development and maintenance such as kinesin-based transport (Chapter I), and (ii) treatment of microtubules with pharmacological agents such as paclitaxel and benomyl also generate structurally and functionally diverse microtubules (Chapter II), whose complex behavioral signatures can be detected and characterized by enhanced imaging and high-level statistical analyses to reveal novel mechanistic insights (Chapter III).

Indexing (document details)
Advisor: Feinstein, Stuart C.
Commitee:
School: University of California, Santa Barbara
School Location: United States -- California
Source: DAI-B 70/02, Dissertation Abstracts International
Source Type: DISSERTATION
Subjects: Molecular biology, Neurosciences, Cellular biology
Keywords: Kinesin, Microtubules, Neurodegenerative disease, Neuronal development, Tau protein
Publication Number: 3347590
ISBN: 9781109032208
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