With PQDT Open, you can read the full text of open access dissertations and theses free of charge.
About PQDT Open
Search
This thesis describes the efforts of Professor James Leighton and myself toward the construction of the core structure of isocyclocitrinol. Our first two approaches toward the 10-membered ring system using ring closing metathesis are discussed. The next chapter discusses the new approaches toward the synthesis of the cyclopentane piece cumulating in the successful epoxy-silane approach. The next three chapters discuss the macrocyclic Suzuki, ketene-aldeyde [2+2], and Ramberg-Bäcklund strategy. Finally, our efforts in performing a ring-contracting Ireland-Claisen reaction for the construction of the 10-membered ring are discussed.
Advisor: | Leighton, James L. |
Commitee: | |
School: | Columbia University |
School Location: | United States -- New York |
Source: | DAI-B 69/10, Dissertation Abstracts International |
Source Type: | DISSERTATION |
Subjects: | Organic chemistry |
Keywords: | Ireland-Claisen reaction, Isocyclocitrinol, Macrolactones, Ring-closing metathesis, Transannular Cope |
Publication Number: | 3333478 |
ISBN: | 978-0-549-85600-9 |