Dissertation/Thesis Abstract

Comparing levels of NDH-1 dehydrogenase activity in different mycobacterial species
by Azogue, Sharon, M.S., University of Maryland, College Park, 2008, 62; 1465422
Abstract (Summary)

The nuoG gene of Mycobacterium tuberculosis (Mtb) has the ability to inhibit host cell apoptosis. This ability is a virulence factor and does not exist in facultative pathogenic and non-pathogenic mycobacterial species. NuoG is part of the NDH-1 complex, and this study addressed the potential link between the role of NuoG in apoptosis inhibition and the biochemical activity of the NDH-1 complex. Different mycobacterial species were tested for their NDH-1 activities. Among the bacteria tested were bacteria transformed with the Mtb nuoG plasmid, or with the almost entire NDH-1 coding region. Surprisingly, the levels of NDH-1 activity did not correlate with apoptosis levels, suggesting a potential independent, novel mechanism by which NuoG inhibits host cell apoptosis.

Indexing (document details)
Advisor: Briken, Volker
Commitee: Lee, Vincent, McIver, Kevin
School: University of Maryland, College Park
Department: Cell Biology & Molecular Genetics
School Location: United States -- Maryland
Source: MAI 47/06M, Masters Abstracts International
Subjects: Microbiology, Biochemistry
Publication Number: 1465422
ISBN: 978-1-109-20053-9
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