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The nuoG gene of Mycobacterium tuberculosis (Mtb) has the ability to inhibit host cell apoptosis. This ability is a virulence factor and does not exist in facultative pathogenic and non-pathogenic mycobacterial species. NuoG is part of the NDH-1 complex, and this study addressed the potential link between the role of NuoG in apoptosis inhibition and the biochemical activity of the NDH-1 complex. Different mycobacterial species were tested for their NDH-1 activities. Among the bacteria tested were bacteria transformed with the Mtb nuoG plasmid, or with the almost entire NDH-1 coding region. Surprisingly, the levels of NDH-1 activity did not correlate with apoptosis levels, suggesting a potential independent, novel mechanism by which NuoG inhibits host cell apoptosis.
| Advisor: | Briken, Volker |
| Commitee: | Lee, Vincent, McIver, Kevin |
| School: | University of Maryland, College Park |
| Department: | Cell Biology & Molecular Genetics |
| School Location: | United States -- Maryland |
| Source: | MAI 47/06M, Masters Abstracts International |
| Source Type: | DISSERTATION |
| Subjects: | Microbiology, Biochemistry |
| Keywords: | |
| Publication Number: | 1465422 |
| ISBN: | 9781109200539 |
