Galanin stimulates food consumption. In contrast, our lab has recently shown that galanin decreases consumption of water. It is generally assumed that galanin modulates feeding and drinking separately, however, this dissertation examines this question more closely suggesting that galanin’s effect on feeding and drinking may result from a more general role in reward related behavior. Specifically, many of the feeding and drinking studies were tested under different experimental conditions; in the feeding studies, rats were always food-sated and had free access to food, while in the drinking studies, the rats were always water-deprived and required to work for the water reward in various operant tasks. Therefore, this study directly tested whether these experimental conditions (deprivation state and response requirement) moderate galanin’s effect on food and water intake. Results revealed that both under food-sated and food-restricted conditions galanin stimulates food consumption, therefore deprivation state does not moderate galanin’s effect on food or water consumption. However when required to work for the food reward using an operant progressive ratio task in which access to each reward is dependent on lever pressing, there was no stimulatory effect of galanin on food consumption. These results show that galanin’s effect on food consumption is limited to conditions where access to food is response-independent and that galanin has differential effects on food and water consumption. The results of this study imply that galanin may cause an increase in food consumption by altering its rewarding value or by interacting with other brain systems important for food consumption relative to food motivation.
|Advisor:||Robinson, John K.|
|School:||State University of New York at Stony Brook|
|School Location:||United States -- New York|
|Source:||DAI-B 71/05, Dissertation Abstracts International|
|Subjects:||Psychobiology, Neurobiology, Nutrition, Experimental psychology|
|Keywords:||Food, Galanin, Reward, Water|
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