HIV-associated neurological disease is a poorly understood condition that continues to increase in prevalence even with the advent of highly active antiretroviral therapy (HAART). As with HIV-infected humans, pigtailed macaques (Macaca nemestrina) infected with simian immunodeficiency virus (SIV) develop signs of neurological disease and dementia with disease course progression. I used an accelerated SIV/macaque model developed by the Johns Hopkins University School of Medicine Retrovirus Laboratory to study SIV replication in the brain of pigtailed macaques during early acute infection Tahar Babas and others (2006) observed a trend towards almost exclusive replication of the neurovirulent viral genotypes SIV/17E-Fr and SIV/DeltaB670 Cl-2 in the brain of macaques beginning as early as 10 days post-inoculation and continuing until terminal infection. Here I report that the neurovirulent, macrophage-tropic viral genotypes SIV/17E-Fr and SIV/DeltaB670 Cl-2 are present in brain RNA at 4 days post-inoculation, and increase in frequency as the disease course progresses.
|Advisor:||Edgington, Nicholas, Zink, Mary Christine|
|School:||Southern Connecticut State University|
|School Location:||United States -- Connecticut|
|Source:||MAI 48/04M, Masters Abstracts International|
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