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Dissertation/Thesis Abstract

Effect of the Acute Phase Response on Dietary Protein Choice in Cockatiels
by Hernandez, Robert A., M.S., University of California, Davis, 2020, 56; 28255607
Abstract (Summary)

When confronted with a novel pathogen, animals undergo a series of innate responses collectively recognized as inflammation, initiated by sequential events known as the acute phase response (APR). This response is primarily mediated by the liver, which produces acute phase proteins (APPs) that facilitate inflammation and tissue repair. Despite there being a drastically increased demand for amino acid substrates to promote APP production, studies examining dietary protein requirements during an immunological response are largely limited to the effects of long-term malnutrition and it is still unknown to what extent dietary protein is needed to sustain an APR in a healthy individual. By investigating the relationship between the APR and dietary protein requirements, important knowledge can be gained towards understanding the impact of hepatic function on overall amino acid metabolism in response to infection, trauma, and inflammation.

The primary aim of this thesis was to determine how altered hepatic function during an APR impacts the dietary protein choice in cockatiels (Nymphicus hollandicus). To address this aim, cockatiels were injected with the endotoxin lipopolysaccharide (LPS) at a concentration of 1mg/kg and dietary choices between two diets containing differing levels of dietary protein were quantified. LPS injection significantly depressed visitation (P = .0001) to and consumption (P < .0001) of both the low and the high protein diets, but the difference in feed intake suppression between the two diets indicate an inclination for higher levels of dietary protein during the APR. These results demonstrate that the APR in cockatiels does not absolve the dietary requirement of protein, but instead may increase the amount needed to facilitate a proper immunological response. This information can provide a basis for further investigation on the role of dietary protein on cytokine expression and its involvement as a substrate for APP synthesis during the APR.

Indexing (document details)
Advisor: Hahn, Thomas P., Klasing, Kirk C.
Commitee: Hahn, Thomas P., Klasing, Kirk C., Blatchford, Richard
School: University of California, Davis
Department: Avian Sciences
School Location: United States -- California
Source: MAI 82/8(E), Masters Abstracts International
Subjects: Animal sciences
Keywords: Acute phase protein, Acute phase response, Cockatiels, Dietary protein, Lipopolysaccharide, Liver
Publication Number: 28255607
ISBN: 9798582531630
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