When confronted with a novel pathogen, animals undergo a series of innate responses collectively recognized as inflammation, initiated by sequential events known as the acute phase response (APR). This response is primarily mediated by the liver, which produces acute phase proteins (APPs) that facilitate inflammation and tissue repair. Despite there being a drastically increased demand for amino acid substrates to promote APP production, studies examining dietary protein requirements during an immunological response are largely limited to the effects of long-term malnutrition and it is still unknown to what extent dietary protein is needed to sustain an APR in a healthy individual. By investigating the relationship between the APR and dietary protein requirements, important knowledge can be gained towards understanding the impact of hepatic function on overall amino acid metabolism in response to infection, trauma, and inflammation.
The primary aim of this thesis was to determine how altered hepatic function during an APR impacts the dietary protein choice in cockatiels (Nymphicus hollandicus). To address this aim, cockatiels were injected with the endotoxin lipopolysaccharide (LPS) at a concentration of 1mg/kg and dietary choices between two diets containing differing levels of dietary protein were quantified. LPS injection significantly depressed visitation (P = .0001) to and consumption (P < .0001) of both the low and the high protein diets, but the difference in feed intake suppression between the two diets indicate an inclination for higher levels of dietary protein during the APR. These results demonstrate that the APR in cockatiels does not absolve the dietary requirement of protein, but instead may increase the amount needed to facilitate a proper immunological response. This information can provide a basis for further investigation on the role of dietary protein on cytokine expression and its involvement as a substrate for APP synthesis during the APR.
|Advisor:||Hahn, Thomas P., Klasing, Kirk C.|
|Commitee:||Hahn, Thomas P., Klasing, Kirk C., Blatchford, Richard|
|School:||University of California, Davis|
|School Location:||United States -- California|
|Source:||MAI 82/8(E), Masters Abstracts International|
|Keywords:||Acute phase protein, Acute phase response, Cockatiels, Dietary protein, Lipopolysaccharide, Liver|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be