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Dissertation/Thesis Abstract

A Study of Additive Manufacturing as a Tool to Create Neomycin Loaded Degradable Poly-L-Lactic Acid Mats Coated with Polyethylene Glycol for a Dermal Wound Healing Model
by Singh, Mahima, Ph.D., University of the Sciences in Philadelphia, 2021, 130; 28315773
Abstract (Summary)

Poly-L-Lactic acid (PLLA) blended with Polyethylene glycol (PEG) was studied for its viability as a dermal mat. PLLA mats were manufactured using an additive manufacturing process (3D printing). These mats were further blended with PEG to improve the physical properties of PLLA. The aim of the project was to build a dermal mat with a surface providing controlled porosity, and drug release capabilities. Our goal was to find the PLLA-PEG mat blend with optimal physical characteristics, cellular attachment and in vivo compatibility for dermal wound healing. The mat provides a protective barrier for the dermal wound, supports regeneration of dermal fibroblasts and was loaded with an antibacterial agent (neomycin). Certain parameters such as tensile strength, young’s modulus, crystallinity, and surface imaging were used to determine the most suitable dermal mat. In vitro release studies were used to show an antibiotic flux to minimize wound site infections. These factors were then analyzed to find the most viable mats to test for cellular attachment and viability. The manufacturing and utilization of PLLA blended with PEG as a dermal mat using additive technology, specifically, using a hot melt extruder for skin regeneration scaffolds is not very well characterized. Our project offered valuable insights into wound healing and tissue regeneration as well as the feasibility of 3D printing as a manufacturing tool.

Indexing (document details)
Advisor: Jonnalagadda, Sriramakamal
Commitee: Ofner, Clyde, III, Gupta, Pardeep, Rane, Anuja
School: University of the Sciences in Philadelphia
Department: Pharmaceutics
School Location: United States -- Pennsylvania
Source: DAI-B 82/8(E), Dissertation Abstracts International
Source Type: DISSERTATION
Subjects: Pharmaceutical sciences
Keywords: 3D printing, Antibiotic, Drug delivery, Poly lactic acid, Polyethylene glycol, Scaffold
Publication Number: 28315773
ISBN: 9798569967766
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