6-Phenyloxane-2,4-diones have been previously reported to have antimicrobial activity. These compounds, as well as their derivatives, have been isolated from a variety of plants, bacteria, and fungi. Examples of naturally occurring 6-phenyloxane-2,4-diones with antimicrobial activity are Podoblastins, Corallopyronins, Myxopyronins, Pseudopyronines, Fusapyrone, and Germicidins. The aforementioned products were isolated from Podophyllum peltatum, Corallococcus (Myxococcus) coralloides, Myxococcus fulvus, Pseudomonas mosselii, Fusarium semitectum, and Streptomyces viridochromogenes respectively and showed significant antimicrobial activity. Additionally, isomers of each compound had varying activity, thus providing evidence that the choice of substituents is a major determinant of biological activity. One objective of my research is to identify a minimum inhibitory concentration (MIC) procedure that provides reproducible antimicrobial susceptibility results for new synthetic derivatives of 6-phenyloxane-2,4-diones. New synthetic derivatives of 6-phenyloxane-2,4-diones containing substituents that model recurring patterns of functional groups seen in naturally occurring antimicrobial products were subjected to antimicrobial susceptibility testing (AST). Ultimately, this thesis explores novel synthetic derivatives to gain a better understanding of substituent placement as a function of antimicrobial activity of 6-phenyloxane-2,4-diones.
|Commitee:||Fry, Michelle, Flint, Edward|
|Department:||Chemistry and Biochemistry|
|School Location:||United States -- Illinois|
|Source:||MAI 82/8(E), Masters Abstracts International|
|Subjects:||Microbiology, Organic chemistry, Pharmaceutical sciences, Biochemistry, Plant sciences|
|Keywords:||Antibiotics, Antimicrobial resistance, Bacteria, Fungi, Minimum inhibitory concentration (MIC)|
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