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Dissertation/Thesis Abstract

Antimicrobial Activity of 6-Arylpyran-2,4-Diones
by Philips, Cassandra, M.S., Bradley University, 2020, 111; 28259586
Abstract (Summary)

6-Phenyloxane-2,4-diones have been previously reported to have antimicrobial activity. These compounds, as well as their derivatives, have been isolated from a variety of plants, bacteria, and fungi. Examples of naturally occurring 6-phenyloxane-2,4-diones with antimicrobial activity are Podoblastins, Corallopyronins, Myxopyronins, Pseudopyronines, Fusapyrone, and Germicidins. The aforementioned products were isolated from Podophyllum peltatum, Corallococcus (Myxococcus) coralloides, Myxococcus fulvus, Pseudomonas mosselii, Fusarium semitectum, and Streptomyces viridochromogenes respectively and showed significant antimicrobial activity. Additionally, isomers of each compound had varying activity, thus providing evidence that the choice of substituents is a major determinant of biological activity. One objective of my research is to identify a minimum inhibitory concentration (MIC) procedure that provides reproducible antimicrobial susceptibility results for new synthetic derivatives of 6-phenyloxane-2,4-diones. New synthetic derivatives of 6-phenyloxane-2,4-diones containing substituents that model recurring patterns of functional groups seen in naturally occurring antimicrobial products were subjected to antimicrobial susceptibility testing (AST). Ultimately, this thesis explores novel synthetic derivatives to gain a better understanding of substituent placement as a function of antimicrobial activity of 6-phenyloxane-2,4-diones.

Indexing (document details)
Advisor: Andersh, Bradley
Commitee: Fry, Michelle, Flint, Edward
School: Bradley University
Department: Chemistry and Biochemistry
School Location: United States -- Illinois
Source: MAI 82/8(E), Masters Abstracts International
Subjects: Microbiology, Organic chemistry, Pharmaceutical sciences, Biochemistry, Plant sciences
Keywords: Antibiotics, Antimicrobial resistance, Bacteria, Fungi, Minimum inhibitory concentration (MIC)
Publication Number: 28259586
ISBN: 9798569977758
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