This study poses the questions as to the extent to which openness and individual absorptive capacity explain innovativeness and the extent to which interpersonal lateral trust and vertical trust interact with openness and with individual absorptive capacity in explaining innovativeness. The study employed a quantitative nonexperimental explanatory cross-sectional survey research design through an anonymous online survey platform. The study drew from the broader sample population of over 2 million managers in the U.S. biotech and health-tech industries. Managers were from Research and Development (R&D), Information Technology (IT), Marketing, Strategy, and Innovation and were responsible for open innovation activities on behalf of the firm. A sample of N = 101 participated in the study. Hierarchical multiple linear regression analysis was performed to assess the relationships. The findings reveal that individual absorptive capacity, individual openness, and interpersonal lateral and vertical trust explain innovativeness. Interpersonal lateral trust influences the contribution of individual openness in explaining individual innovativeness but does not exert influence between individual absorptive capacity and individual innovativeness. Interpersonal vertical trust influences the contribution of individual absorptive capacity and individual openness in explaining individual innovativeness.