Colorectal screening (CRCS) programs are an important part of the national health screening processes however, many patients are still not screened according to guidelines. The American Cancer Society's (ACS) CRCS guideline outlines the best practice of patient navigators to ensure timely screening occur at provider appointments. The project site's ambulatory gynecology practice was not meeting the organization's goal for CRCS completion within 30 days of a provider appointment. The purpose of this quantitative, quasi-experimental quality improvement project was to determine if the implementation of the ACS's CRCS guidelines using patient navigators would impact 30-day CRCS completion rates among average-risk patients 50 to 75 years of age in a gynecology practice in Southern California, over four weeks. Ajzen's theory of planned behavior, Rosenstock's health belief model, and Pender's health promotion model, were the theoretical foundations. The total sample size was 53, n = 27 in the comparative group, and n = 26 in the implementation group. Data were extrapolated from the site's electronic health record. A chi-square test was used to analyze the comparison and implementation group's data, resulting in x 2(1, N = 53) = 4.44, p = .035, which showed both a statistical and clinically significant difference. Clinical significance was demonstrated in the increase from 22.2% to 50% in CRCS with patient navigator use. Recommendations included the repetition of the project extending the timeframe at a larger clinical site adding CRCS education to providers and nurses.