Betrayal Trauma Theory and Cultural Betrayal Trauma Theory provide frameworks for understanding the distinct harm of trauma perpetrated by a close other (i.e., high betrayal trauma) and trauma perpetrated by a member of the same marginalized group (i.e., cultural betrayal trauma), respectively. Research supports the detrimental, individual impact of betrayal trauma on health symptoms, but additional research is needed to understand the multiplicative effect of betrayal trauma among various marginalized groups. The current study, thus, examined the unique and multiplicative effects of high betrayal trauma and cultural betrayal trauma on psychological and physical health symptoms in a Latina/o/x sample. Latina/o/x undergraduate students (N = 218) participated in an online survey about their experiences of interpersonal violence, betrayal trauma, and current psychological and physical health symptoms. A significant interaction was observed for general psychological symptoms and anxiety symptoms specifically; tests for simple effects indicated that cultural betrayal trauma had a more salient effect on psychological and anxiety symptoms for participants who reported fewer experiences of high betrayal trauma. Findings may inform more targeted support services after experiences of trauma and underscore the need for more research on the multiplicative effects of betrayal trauma.